Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 14th International Conference on Microbial Interactions & Microbial Ecology Mercure Hotel Wien Westbahnhof ,Vienna, Austria.

Day 1 :

Conference Series Microbial Interactions 2019 International Conference Keynote Speaker Bian Zhaoxiang, photo
Biography:

Prof Bian Zhaoxiang had been educated in Nanjing University of Traditional Chinese Medicine (TCM). Beijing University of TCM and Guangzhou University ofTCM; and was conferred the Ph.D. degree in Integrated Chinese and Western Medicine in 1994. Currently, he is the Associate Vice-President, Chair Professor of School of Chinese Medicine, Director of Clinical Division and Associate Director of Institute of Creativity of Hong Kong Baptist University. He is also the Honorary Professor of the Shanghai University of TCM, and the Chinese Academy of Chinese Medical Sciences, China. Prof. Bian's research focuses mainly on the relationship between psychological stress and digestive diseases, especially on colorectal cancer irritable bowel syndrome (IBS) and inflammatory bowel disease (IBO) and related new drug discovery and clinical trial design, implementation and reporting with Chinese Medicine

 

Abstract:

Bile acid (BA) overexcretion, strongly linking with the severity of bowel symptoms, affects a considerable population of diarrhea-predominant irritable bowel syndrome (IBS-D), Some genetic and metabolic mechanisms derived from the host have been documented, however the role of gut microbiota has received little attention. To investigate gutmicrobiota and its effect on BA metabolism in IBS-D, a series of metabolic and microbial experiments were performed from bedside to bench. Fecal metagenomic analysis identified a specific enterotype characterized by enrichment of Clostridium in IBS-D cases with BA overexcretion. Abundant Clostridium species showed positive association with human fecal total BA and serum C4 levels, but reversely correlated with serum FGF19. Further, mouse experiments with bacterial manipulation found that enrichment of Clostridium species in the cecal lumens leads to elevation of fecal total BA level and taurine-conjugated BA contents in the liver and ileal contents, along with differential expressions ofhepatic BA synthetase CYP7A1 and ileal feedback regulator FGF15. Mechanistic analyses revealed such microbiotadriven BA synthetic dysregulation is involved in inhibition of FXR-mediated feedback signaling. This study discloses the potential contribution of Clostridium-enriched enterotype in BA overexcretion in IBS-D and also suggest the importance of enterotype classification in pathogenesis and diagnosis for IBS.

Conference Series Microbial Interactions 2019 International Conference Keynote Speaker Narjes H Dashti photo
Biography:

Narjes H Dashti works as an Associate Professor of Microbiology in the Department of Biological Sciences, Faculty of Science at Kuwait University. She has completed her Bachelor’s degree in Soil Microbiology at Kuwait University. Afterwards, she took her Master’s degree in the same field at Oregon State University, USA followed by a PhD at McGill University, Canada. Her research interests include plant pathology, virology, soil microbiology, microbial bioremediation and hydrocarbon degradation. She has over 21 publications, 2 chapters Chapter Titled" PGPR to Alleviate the stress of Suboptimal Root Zone Temperature on Leguminous Plant Growth", in the book “Use of Microbes for the Alleviation of Soil Stress”, volume 1, 2013, Springer, Chapter Titled" Soybean production and suboptimal root zone temperatures" in the book “Environmental Stresses in Soybean Production” 2015 Elsevier, academic press, volume 1. She has presented many of her finding in both national and international conferences

Abstract:

Viruses in general and bacteriophages infecting cyanobacteria (cyanophages) in particular, are abundant in the marine environment and are of major ecological significance. Marine phytoplankton’s are photosynthetic free floating organisms that are major contributor to primary productivity in marine environment as a part of the balance of the marine ecosystem. Many phytoplankton’s can cause occasional blooms (such as red tides caused by dinoflagellates) that might be of harmful effects on the environment, and even have economic effects on fisheries and the fish industry. Such red tides, that kill fish in a huge number, have been reoccurring in Kuwaiti seawater in the past decade and it might be seen again in the future. Viruses are considered to be a major controlling factor for phytoplankton populations and blooming. This cyanophages were successfully detected and phage DNA molecules were isolated by using polymerase  chain reaction (PCR) technology in as little as 1 ul of Kuwaiti seawater directly. Specific primers were used in PCR mix, and 6% polyacrylamide gel electrophoresis (PAGE) was used to visualize the amplified phage DNA bands. Nanoscopy was used to detect and study the structure of the isolated phages and it was identified to be a virulent strain of phage, with T4 being the type species of the family of contractile tailed ds DNA phages composing the family Myoviridae